Acetonitrile → HCID 178507819, 화합물

HRID 1957518노트

반응식

HRID 1957518 반응식
[NH2:1][C:2]1[C:7]2[O:8][CH2:9][CH2:10][O:11][C:6]=2[C:5](C(O)=O)=[CH:4][C:3]=1[Cl:15].[C:16](#[N:18])[CH3:17]>>[NH2:1][C:2]1[C:7]2[O:8][CH2:9][CH2:10][O:11][C:6]=2[CH:5]=[CH:4][C:3]=1[Cl:15].[NH:18]1[C-:16]=[CH:17][N:1]=[CH:2]1

참가 물질

3

반응물 2

HCID 6342AcetonitrileHCID 117759978-Amino-7-chloro-2,3-dihydro-1,4-benzodioxine-5-carboxylic acid

생성물 1

HCID 178507819HCID 178507819, 화합물

실험 절차

To a stirred solution of 8-amino-7-chloro-1,4-benzodioxan-5-carboxylic acid (prepared from the corresponding 7-H acid (prepared as in GB 1571278) by chlorination of the protected form) (1.10 g) in acetonitrile was added biscarbonyldiimidazole (0.77 g). The reaction mixture was stirred at room temperature for 1.5 hours. The solvent was removed under reduced pressure to afford crude 8-amino-7-chloro-1,4-benzodioxan-5-imidazolide.

후처리

  1. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-41361a8672a44e33b8496e820a715ce8
출처 데이터셋
uspto-grants-1998_07
특허 번호
US05786372

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