Ethanol → 1-(1,2-Benzisoxazol-3-yl)ethanol
반응식
C([O:4][CH:5]([C:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[O:9][N:8]=1)[CH3:6])(=O)C.[OH-].[K+].C(O)C>O>[O:9]1[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[C:7]([CH:5]([OH:4])[CH3:6])=[N:8]1참가 물질
5
실험 절차
A mixture of 2.6 g of 3-(1-acetoxyethyl)-1,2-benzisoxazole, 0.9 g of potassium hydroxide, 40 ml of ethanol and 3 ml of water is stirred for 1 h at room temperature. The reaction mixture is then concentrated under vacuum and diluted with water. This aqueous phase is extracted three times with diethyl ether, the combined ethereal extracts are then washed with a saturated solution of sodium chloride and dried over sodium sulfate, giving 1-(1,2-benzisoxazol-3-yl)ethanol as an oil having a refractive index nD20 of 1.5555.
후처리
- concentrationThe reaction mixture is then concentrated under vacuum
- additiondiluted with water
- extractionThis aqueous phase is extracted three times with diethyl ether
- washthe combined ethereal extracts are then washed with a saturated solution of sodium chloride
- dry with materialdried over sodium sulfate
출처 및 근거
- ORD 기록
- ord-e46a4847bc584047af11a68dbe52fe30
- 출처 데이터셋
- uspto-grants-1998_07
- 특허 번호
- US05786374
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