Sodium methanesulfinate → 1-Methylsulfonylmethyl-3-nitro-5-trifluoromethyl-benzene

HRID 1957956노트

반응식

HRID 1957956 반응식
Cl[CH2:2][C:3]1[CH:8]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:6]=[C:5]([N+:13]([O-:15])=[O:14])[CH:4]=1.[Na+].[CH3:17][S:18]([O-:20])=[O:19]>CO>[CH3:17][S:18]([CH2:2][C:3]1[CH:8]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:6]=[C:5]([N+:13]([O-:15])=[O:14])[CH:4]=1)(=[O:20])=[O:19]

참가 물질

4

반응물 2

HCID 2733271Sodium methanesulfinateHCID 684250951-(Chloromethyl)-3-nitro-5-(trifluoromethyl)benzene

생성물 1

HCID 684233041-Methylsulfonylmethyl-3-nitro-5-trifluoromethyl-benzene수율 92.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 1-chloromethyl-3-nitro-5-trifluoromethyl-benzene (520 mg; 2.170 mmol) and methanesulfinic acid sodium salt (664 mg; 6.511 mmol) in Methanol (10 ml) of was refluxed overnight. The reaction was then cooled to room temperature and the product precipitated was filtered and diluted with dichloromethane. The solid was removed and the organic phase was concentrated in vacuo 520 mg (2 mmol; 85% yield) of 1-methylsulfonylmethyl-3-nitro-5-trifluoromethyl-benzene were obtained.

후처리

  1. customthe product precipitated
  2. filtrationwas filtered
  3. additiondiluted with dichloromethane
  4. customThe solid was removed

출처 및 근거

ORD 기록
ord-c521c703272c4832b7d389f592e4fd42
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08410100B2

반응 노트

불러오는 중…