Potassium Carbonate → [(2-Chloro-5-nitro-pyrimidin-4-yl)-isopropyl-amino]-acetic acid ethyl ester

HRID 1957985

반응식

HRID 1957985 반응식
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=1.[CH2:12]([O:14][C:15](=[O:21])[CH2:16][NH:17][CH:18]([CH3:20])[CH3:19])[CH3:13].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O.O>[CH2:12]([O:14][C:15](=[O:21])[CH2:16][N:17]([C:6]1[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=[C:2]([Cl:1])[N:7]=1)[CH:18]([CH3:20])[CH3:19])[CH3:13]

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 351625Ethyl 2-((propan-2-yl)amino)acetateHCID 5212662,4-Dichloro-5-nitropyrimidine

생성물 1

HCID 59286164[(2-Chloro-5-nitro-pyrimidin-4-yl)-isopropyl-amino]-acetic acid ethyl ester수율 72%

시약·촉매·용매 2

HCID 180Acetone용매HCID 962Water용매

실험 절차

2,4-Dichloro-5-nitro-pyrimidine (40 g; 0.207 mol) was added to a cooled (0-10° C.) solution of isopropylamino-acetic acid ethyl ester (30 g; 0.207 mol) in 300 ml of acetone. A solution of potassium carbonate (28.5 g; 0.207 mol) in water was then added to the cooled reaction mixture. The reaction mixture was allowed to reach room temperature and was maintained at that temperature until complete conversion of the starting material into the desired product.

후처리

  1. customto reach room temperature

출처 및 근거

ORD 기록
ord-412617fd421040c9b5955d19df5f669e
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08410100B2

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