Sodium Carbonate → Methyl N-cyano-2-methylmorpholine-4-carbimidothioate
반응식
Cl.[CH3:2][CH:3]1[O:8][CH2:7][CH2:6][NH:5][CH2:4]1.[C:9]([N:11]=[C:12](SC)[S:13][CH3:14])#[N:10].C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[C:9]([N:11]=[C:12]([N:5]1[CH2:6][CH2:7][O:8][CH:3]([CH3:2])[CH2:4]1)[S:13][CH3:14])#[N:10]참가 물질
5
실험 절차
A mixture of 2-methylmorpholine hydrochloride (1.0 g, 9.9 mmol), dimethyl cyanocarbonimidodithioate (1.45 g, 9.9 mmol) and sodium carbonate (0.2 g, 1.9 mmol) in ethanol (50 mL) was stirred at ambient temperature overnight. The reaction mixture was concentrated and purified through silica gel chromatography to give the desired product (1.25 g, 63%). LC-MS: 200 (MH+).
후처리
- concentrationThe reaction mixture was concentrated
- custompurified through silica gel chromatography
출처 및 근거
- ORD 기록
- ord-59e310a4c4df43d89511b21394ac8827
- 출처 데이터셋
- uspto-grants-2013_04
- 특허 번호
- US08410095B2
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