5-Bromo-2-isobutyl-1,3-thiazole → HCID 58207904, 화합물

반응식

Br[C:2]1[S:6][C:5]([CH2:7][CH:8]([CH3:10])[CH3:9])=[N:4][CH:3]=1.[C:11]1([CH3:29])[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[C:17]1[C:18]2[N:19]([CH:26]=[CH:27][N:28]=2)[CH:20]=[C:21](B(O)O)[CH:22]=1>>[CH2:7]([C:5]1[S:6][C:2]([C:21]2[CH:22]=[C:17]([C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[CH3:29])[C:18]3[N:19]([CH:26]=[CH:27][N:28]=3)[CH:20]=2)=[CH:3][N:4]=1)[CH:8]([CH3:10])[CH3:9]

참가 물질

반응물 2

HCID 206967745-Bromo-2-isobutyl-1,3-thiazole

HCID 67008224HCID 67008224, 화합물

생성물 1

HCID 58207904HCID 58207904, 화합물

실험 절차

Example 189 was prepared using the procedure describe for Example 34, step 4, from 5-bromo-2-isobutylthiazole and 8-o-tolylimidazo[1,2-a]pyridin-6-ylboronic acid. LCMS (Conditions C): Tr 2.86 min.; (M+H)+: 348.0

후처리

customExample 189 was prepared
customTr 2.86 min.

출처 및 근거

ORD 기록: ord-2d6a382fec494bea98e9c37bef41469e
출처 데이터셋: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08410128B2

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