Dimethylamine → Methyl 4-(Dimethylamino)methyl-3-methoxybenzoate

HRID 1958809노트

반응식

HRID 1958809 반응식
[CH3:1][NH:2][CH3:3].Br[CH2:5][C:6]1[CH:15]=[CH:14][C:9]([C:10]([O:12][CH3:13])=[O:11])=[CH:8][C:7]=1[O:16][CH3:17]>C(O)C.C1COCC1.O.C([O-])([O-])=O.[Na+].[Na+]>[CH3:1][N:2]([CH2:5][C:6]1[CH:15]=[CH:14][C:9]([C:10]([O:12][CH3:13])=[O:11])=[CH:8][C:7]=1[O:16][CH3:17])[CH3:3]

참가 물질

7

반응물 2

HCID 674DimethylamineHCID 2759828Methyl 4-(bromomethyl)-3-methoxybenzoate

생성물 1

HCID 21182956Methyl 4-(Dimethylamino)methyl-3-methoxybenzoate

시약·촉매·용매 4

HCID 702Ethanol용매HCID 962Water용매HCID 8028Tetrahydrofuran용매HCID 10340Sodium Carbonate용매

실험 절차

To a solution of dimethyl amine (0.9 mL of a 5.6 M solution in ethanol) in THF (20 mL), a solution of methyl 4-(bromomethyl)-3-methoxybenzoate (500 mg, 2.06 mmol) was added. The mixture was stirred at rt for 35 min before it was diluted with water (150 mL) and sat. aq. Na2CO3-solution (50 mL) and extracted with EA (70 mL). The org. extract was separated, dried over Na2SO4, filtered, evaporated and dried to give methyl 4-dimethylaminomethyl-3-methoxy-benzoate as a colourless oil (420 mg). LC-MS: tR=0.61 min, [M+1]+=224.04.

후처리

  1. extractionextracted with EA (70 mL)
  2. extractionextract
  3. customwas separated
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. customevaporated
  7. customdried

출처 및 근거

ORD 기록
ord-b1fe79b1de2c47a7ba4290b41e80169d
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08410151B2

반응 노트

불러오는 중…