1-(3,4-Dichlorophenyl)-4,5-dihydro-1H-pyrazol-3-amine → 1-(3,4-Dichlorophenyl)-1H-pyrazol-3-amine

HRID 1958880노트

반응식

HRID 1958880 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[CH2:13][CH2:12][C:11]([NH2:14])=[N:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]>ClCCl.O=[Mn]=O>[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[CH:13]=[CH:12][C:11]([NH2:14])=[N:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

참가 물질

4

반응물 1

HCID 155806881-(3,4-Dichlorophenyl)-4,5-dihydro-1H-pyrazol-3-amine

생성물 1

HCID 234642861-(3,4-Dichlorophenyl)-1H-pyrazol-3-amine

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 6344Dichloromethane용매

실험 절차

To a solution of 1-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-3-amine (0.62 g, 2.7 mmol) in dichlorometane (45 ml), MnO2 (1.04 g, 10.8 mmol) was added and the mixture stirred at room temperature during 4 hrs. The final mixture was filtered throught decalite and the filtered solution evaporated to dryness in vacuo. The red crude solid was crystallized in ethyl ether/petroleum ether yielding 0.46 g of 1-(3,4-dichlorophenyl)-1H-pyrazol-3-amine.

후처리

  1. filtrationThe final mixture was filtered
  2. customthe filtered solution evaporated to dryness in vacuo
  3. customThe red crude solid was crystallized in ethyl ether/petroleum ether yielding 0.46 g of 1-(3,4-dichlorophenyl)-1H-pyrazol-3-amine

출처 및 근거

ORD 기록
ord-7f20c11754394a0bb41242f36ee119bd
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08410159B2

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