Water → 2-chloro-N-(1-(3,4-dichlorophenyl)-1H-pyrazol-3-yl)acetamide

HRID 1958881노트

반응식

HRID 1958881 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[CH:13]=[CH:12][C:11]([NH2:14])=[N:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].C(N(CC)CC)C.[Cl:22][CH2:23][C:24](Cl)=[O:25].O>O1CCCC1>[Cl:22][CH2:23][C:24]([NH:14][C:11]1[CH:12]=[CH:13][N:9]([C:4]2[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=2)[N:10]=1)=[O:25]

참가 물질

6

반응물 4

HCID 962WaterHCID 6577Chloroacetyl chlorideHCID 8471TriethylamineHCID 234642861-(3,4-Dichlorophenyl)-1H-pyrazol-3-amine

생성물 1

HCID 577054132-chloro-N-(1-(3,4-dichlorophenyl)-1H-pyrazol-3-yl)acetamide수율 92.9%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution, ice cooled, of 1-(3,4-dichlorophenyl)-1H-pyrazol-3-amine (0.36 g, 1.59 mmol) and triethylamine (0.24 g, 2.38 mmol) in dry tetrahydrofurane (5 ml), 2-chloroacetyl chloride (0.2 g, 1.79 mmol) was added. The mixture was stirred overnight at room temperature, water added and the organic solvent evaporated in vacuo. The resulting suspension was filtered and dried yielding 0.45 g of 2-chloro-N-(1-(3,4-dichlorophenyl)-1H-pyrazol-3-yl)acetamide as a beige colour solid.

후처리

  1. additionwas added
  2. customthe organic solvent evaporated in vacuo
  3. filtrationThe resulting suspension was filtered
  4. customdried

출처 및 근거

ORD 기록
ord-2a9f8e22263f4f7d8b4a21741c23a625
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08410159B2

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