Tert-Butylamine → Methyl 5-[(tert-butylamino)sulfonyl]-2-furoate
반응식
Cl[S:2]([C:5]1[O:9][C:8]([C:10]([O:12][CH3:13])=[O:11])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[C:14]([NH2:18])([CH3:17])([CH3:16])[CH3:15]>C(Cl)Cl>[C:14]([NH:18][S:2]([C:5]1[O:9][C:8]([C:10]([O:12][CH3:13])=[O:11])=[CH:7][CH:6]=1)(=[O:4])=[O:3])([CH3:17])([CH3:16])[CH3:15]참가 물질
4
실험 절차
To a solution of methyl 5-(chlorosulfonyl)-2-furoate (3.0 g) in DCM (100 mL) was added tert-butylamine (3.6 mL). After stirring at room temperature for 2 days the mixture was filtered through a pad of celite, washing with DCM (2×10 mL). The filtrate was evaporated to dryness in vacuo. The resulting crude residue was purified by column chromatography using EtOAc/isohexane (2:8) as eluent to give the subtitle compound as a foam. Yield: 2.75 g.
후처리
- filtrationwas filtered through a pad of celite
- washwashing with DCM (2×10 mL)
- customThe filtrate was evaporated to dryness in vacuo
- customThe resulting crude residue was purified by column chromatography
출처 및 근거
- ORD 기록
- ord-925be3d7e08f410692da98895d8a4cf9
- 출처 데이터셋
- uspto-grants-2013_04
- 특허 번호
- US08410123B2
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