HCID 86619885, 화합물 → 1,2,3,4-Tetrahydroisoquinoline-7-sulfonamide

HRID 1959025노트

반응식

HRID 1959025 반응식
C([NH:5][S:6]([C:9]1[CH:18]=[C:17]2[C:12]([CH2:13][CH2:14][N:15](C(=O)C(F)(F)F)[CH2:16]2)=[CH:11][CH:10]=1)(=[O:8])=[O:7])(C)(C)C>C(O)(C(F)(F)F)=O>[CH2:16]1[C:17]2[C:12](=[CH:11][CH:10]=[C:9]([S:6]([NH2:5])(=[O:7])=[O:8])[CH:18]=2)[CH2:13][CH2:14][NH:15]1

참가 물질

3

반응물 1

HCID 86619885HCID 86619885, 화합물2회

생성물 1

HCID 52261,2,3,4-Tetrahydroisoquinoline-7-sulfonamide

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

N-(tert-Butyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide (the product from step i), 1.78 g) was dissolved in TFA and stirred at room temperature for 96 h. The reaction was reduced in vacuo and the residue purified by column chromatography on silica gel 50% EtOAc/50% iso-hexane to give the subtitle compound as a white solid. Yield: 0.65 g

후처리

  1. customthe residue purified by column chromatography on silica gel 50% EtOAc/50% iso-hexane

출처 및 근거

ORD 기록
ord-f6ae1292f80f47468c03cc8cd7891b81
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08410123B2

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