3-amino-6-bromo-N'-(phenylcarbonyl)pyrazine-2-carbohydrazide → 5-Bromo-3-(5-phenyl-1,3,4-oxadiazol-2-yl)pyrazin-2-amine

HRID 1959362노트

반응식

HRID 1959362 반응식
[NH2:1][C:2]1[C:3]([C:9]([NH:11][NH:12][C:13](=[O:20])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=O)=[N:4][C:5]([Br:8])=[CH:6][N:7]=1>O>[Br:8][C:5]1[N:4]=[C:3]([C:9]2[O:20][C:13]([C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)=[N:12][N:11]=2)[C:2]([NH2:1])=[N:7][CH:6]=1

참가 물질

3

반응물 1

HCID 594723553-amino-6-bromo-N'-(phenylcarbonyl)pyrazine-2-carbohydrazide

생성물 1

HCID 580843425-Bromo-3-(5-phenyl-1,3,4-oxadiazol-2-yl)pyrazin-2-amine수율 78%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

Polyphosphonic acid (25 mL of 84% w/v, 256.1 mmol) was heated to 100° C. and treated with 3-amino-N′-benzoyl-6-bromo-pyrazine-2-carbohydrazide (6.82 g, 20.29 mmol) in portions. Analysis after 1 hour showed SM remaining therefore further polyphosphonic acid was added (25 mL of 84% w/v, 256.1 mmol). The reaction was heated for a total of 3 hours and then allowed to cool. Water was added and the mixture allowed to stir to obtain a precipitate which was filtered and dried under vacuum (5.02 g, 78% Yield). MS (ES+) 317.86

후처리

  1. additionfurther polyphosphonic acid was added (25 mL of 84% w/v, 256.1 mmol)
  2. temperatureThe reaction was heated for a total of 3 hours
  3. temperatureto cool
  4. customto obtain a precipitate which
  5. filtrationwas filtered
  6. customdried under vacuum (5.02 g, 78% Yield)

출처 및 근거

ORD 기록
ord-f48e6c0a7d8b4a758f58055e2eb1f729
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08410112B2

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