Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1959525생성일: 2026년 10월 26일
Potassium Carbonate → {3-[5-Amino-1-(5-cyclopropylcarbamoyl-2-methyl-phenyl)-1H-pyrazole-4-carbonyl]-phenoxy}-acetic acid
https://huagongshe.com/reaction/1959525
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | tert-Butyl chloroacetate | HCID 66052 | — |
| 반응물 | 3-[5-amino-4-(3-hydroxy-benzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzamide | HCID 11245836 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | {3-[5-Amino-1-(5-cyclopropylcarbamoyl-2-methyl-phenyl)-1H-pyrazole-4-carbonyl]-phenoxy}-acetic acid | HCID 58088941 | 30.4% |
반응 단계
To a stirred solution of 3-[5-amino-4-(3-hydroxy-benzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzamide (400 mg, 1.06 mmol) and t-butyl chloroacetate (319 mg, 2.12 mmol) in DMF (20 mL) was added K2CO3 (292 mg, 2.12 mmol) and the mixture was heated at 100° C. overnight. The solvent was removed, and the residue was suspended in EtOAc, washed by water, brine, dried over Na2SO4, and concentrated. The crude product was purified by column chromatography on silica gel (EtOAc:Hexane=3:1) to provide the product as a light yellow oil (140 mg, 27%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08410160B2 |
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| 출처 데이터셋 | uspto-grants-2013_04 |
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| ORD ID | ord-a0e6e2b138f6495aa0d75334c672fb21 |
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| 출처 메모 | uspto-grants-2013_04 |
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