Imidazole → 8-Hydroxy-4-(1H-imidazol-yl)-2-methylquinoline
반응식
Cl[C:2]1[C:11]2[C:6](=[C:7]([OH:12])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:13])[CH:3]=1.[NH:14]1[CH:18]=[CH:17][N:16]=[CH:15]1>O1CCOCC1>[N:14]1([C:2]2[C:11]3[C:6](=[C:7]([OH:12])[CH:8]=[CH:9][CH:10]=3)[N:5]=[C:4]([CH3:13])[CH:3]=2)[CH:18]=[CH:17][N:16]=[CH:15]1참가 물질
4
실험 절차
A mixture of 4-chloro-2-methyl-quinolin-8-ol (2.0 g, 10 mmol) and imidazole (3.53 g, 51.8 mmol) in dioxane (20 mL) was heated to reflux for 28 h. The solvent was removed in vacuo and the residue was purified by flash chromatography on silica gel (elution with DCM/methanol 10:1) to give the title compound. MS (m/z): 226.3 [M+H+].
후처리
- temperaturewas heated
- temperatureto reflux for 28 h
- customThe solvent was removed in vacuo
- customthe residue was purified by flash chromatography on silica gel (elution with DCM/methanol 10:1)
출처 및 근거
- ORD 기록
- ord-653e6d7c75f54932bd69a4ffcd6a882c
- 출처 데이터셋
- uspto-grants-2013_04
- 특허 번호
- US08410134B2
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