Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Citric Acid → Bromo-acetic acid 2,4-dinitro-phenyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Citric Acid | HCID 311 | — |
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 2,4-Dinitrophenol | HCID 1493 | — |
| 반응물 | Bromoacetyl bromide | HCID 61147 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Bromo-acetic acid 2,4-dinitro-phenyl ester | HCID 11278141 | — |
반응 단계
Under argon atmosphere bromo-acetyl bromide (2.67 mL, 30.66 mmol) dissolved in DCM (15 mL) was added within 15 min to a mixture of 2,4-dinitro-phenol (5.13 g, 27.88 mmol) and pyridine (2.92 mL, 36.24 mmol) in DCM (40 mL) at 0° C. After 1 h at RT, aqueous citric acid solution (10%, 30 mL) was added to the reaction mixture. The organic layer was dried over Na2SO4, filtered, and concentrated in vacuo. The resulting residue recrystallized from diethyl ether (75 mL) to afford the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08410134B2 |
| 출처 데이터셋 | uspto-grants-2013_04 |
| ORD ID | ord-73231533228d4ba39352ee3bca1e76e9 |
| 출처 메모 | uspto-grants-2013_04 |