N-Methylisopropylamine → 2-Bromo-N-isopropyl-N-methyl-acetamide

HRID 1959572

반응식

HRID 1959572 반응식
[CH:1]([NH:4][CH3:5])([CH3:3])[CH3:2].[N+](C1C=C([N+]([O-])=O)C=CC=1O[C:19](=[O:22])[CH2:20][Br:21])([O-])=O>C(Cl)Cl>[Br:21][CH2:20][C:19]([N:4]([CH:1]([CH3:3])[CH3:2])[CH3:5])=[O:22]

참가 물질

4

반응물 2

HCID 78485N-MethylisopropylamineHCID 11278141Bromo-acetic acid 2,4-dinitro-phenyl ester

생성물 1

HCID 205943482-Bromo-N-isopropyl-N-methyl-acetamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Isopropyl-methyl-amine (154 μL, 1.48 mmol) was added to a stirred solution of bromo-acetic acid 2,4-dinitro-phenyl ester (450 mg, 1.48 mmol) in DCM (4 mL). After stirring for 3 h at room temperature the organic layer was extracted twice with 0.1 M NaOH solution (30 mL). The organic layer was dried over Na2SO4, filtered, and concentrated in vacuo. The resulting title compound was used for the next reaction without purification. MS (m/z): 194.0 [M+H+].

후처리

  1. extractionwas extracted twice with 0.1 M NaOH solution (30 mL)
  2. dry with materialThe organic layer was dried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo
  5. customThe resulting title compound was used for the next reaction without purification

출처 및 근거

ORD 기록
ord-42b1851bbde7487390a5cbecead28780
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08410134B2

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