Triacetoxyperiodinane → HCID 86645365, 화합물

HRID 1959614노트

반응식

HRID 1959614 반응식
CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O.[Cl:23][C:24]1[CH:29]=[CH:28][N:27]=[C:26]([CH2:30][OH:31])[C:25]=1[CH2:32][O:33][CH:34]1[CH2:39][CH2:38][CH2:37][CH2:36][O:35]1>C1COCC1>[Cl:23][C:24]1[CH:29]=[CH:28][N:27]=[C:26]([CH:30]=[O:31])[C:25]=1[CH2:32][O:33][CH:34]1[CH2:39][CH2:38][CH2:37][CH2:36][O:35]1

참가 물질

4

반응물 2

HCID 159087TriacetoxyperiodinaneHCID 67077239HCID 67077239, 화합물

생성물 1

HCID 86645365HCID 86645365, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Dess-Martin periodinane (370 mg. 0.873 mmol) was added to a stirred solution of [4-chloro-3-(tetrahydro-pyran-2-yloxymethyl)-pyridin-2-yl]-methanol (150 mg. 0.582 mmol) in THF (5 mL). After stirring for 2 h at room temperature the reaction was concentrated. Sat. NaHCO3 solution (20 mL) was added and extracted three times with DCM (50 mL). The combined organic layers were dried over Na2SO4 filtered and concentrated in vacuo. The resulting title compound was used for the next reaction without purification. MS (m/z): 255.7 [M+H+].

후처리

  1. concentrationwas concentrated
  2. additionSat. NaHCO3 solution (20 mL) was added
  3. extractionextracted three times with DCM (50 mL)
  4. dry with materialThe combined organic layers were dried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo
  7. customThe resulting title compound was used for the next reaction without purification

출처 및 근거

ORD 기록
ord-f34771091b8047cdbc4552c352c45dfc
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08410134B2

반응 노트

불러오는 중…