Methylamine → HCID 178483385, 화합물

HRID 1959842노트

반응식

HRID 1959842 반응식
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:14]([CH2:15][CH2:16][CH2:17]Br)=[N:13][NH:12][C:11]=1[NH2:19].[CH3:20][NH2:21]>C1COCC1>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:14]([CH2:15][CH2:16][CH2:17][NH:21][CH3:20])=[N:13][NH:12][C:11]=1[NH2:19]

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 178509116HCID 178509116, 화합물

생성물 1

HCID 178483385HCID 178483385, 화합물수율 32%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 4-benzothiazol-2-yl-5-(3-bromopropyl)-2H-pyrazol-3-ylamine (130 mg, 0.39 mmol) and methylamine (5 mL of a 2 M solution in THF, 10 mmol) was stirred at room temperature for 60 hrs. The resulting solid was isolated by filtration, washed with THF, and then with water. The product was air dried to yield 38 mg (32%) of the title compound as an off white solid. MS (m/z, ES+): 288.2 (M+1, 100%).

후처리

  1. customThe resulting solid was isolated by filtration
  2. washwashed with THF
  3. customdried

출처 및 근거

ORD 기록
ord-ba9730bcfda44e219843ae63e21a3455
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08410272B2

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