Trifluoroacetic acid → N-[5-(6-benzyloxy-naphthalen-2-yl)-pyrazolo[1,5-c]pyrimidin-7-yl]-benzene-1,4-diamine

HRID 19606

반응식

HRID 19606 반응식
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15]2[N:20]3[N:21]=[CH:22][CH:23]=[C:19]3[CH:18]=[C:17]([C:24]3[CH:33]=[CH:32][C:31]4[C:26](=[CH:27][CH:28]=[C:29]([O:34][CH2:35][C:36]5[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=5)[CH:30]=4)[CH:25]=3)[N:16]=2)=[CH:10][CH:9]=1)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[CH2:35]([O:34][C:29]1[CH:30]=[C:31]2[C:26](=[CH:27][CH:28]=1)[CH:25]=[C:24]([C:17]1[N:16]=[C:15]([NH:14][C:11]3[CH:12]=[CH:13][C:8]([NH2:7])=[CH:9][CH:10]=3)[N:20]3[N:21]=[CH:22][CH:23]=[C:19]3[CH:18]=1)[CH:33]=[CH:32]2)[C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 67319245{4-[5-(6-Benzyloxy-naphthalen-2-yl)-pyrazolo[1,5-c]pyrimidin-7-ylamino]-phenyl}-carbamic acid tert-butyl ester2회

생성물 1

HCID 67318736N-[5-(6-benzyloxy-naphthalen-2-yl)-pyrazolo[1,5-c]pyrimidin-7-yl]-benzene-1,4-diamine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of {4-[5-(6-benzyloxy-naphthalen-2-yl)-pyrazolo[1,5-c]pyrimidin-7-ylamino]-phenyl}-carbamic acid tert-butyl ester (compound C2)(450 mg), TFA (2 ml) and dichloromethane (10 ml) is stirred 4 h at ambient temperature. The reaction mixture is evaporated and coevaporated with toluene. The residue is partitioned between a aqueous saturated solution of sodium bicarbonate and ethyl acetate. After drying the organic phase is evaporated and the residue is dried in vacuum. A solid in quantitative yield is obtained.

후처리

  1. customThe reaction mixture is evaporated
  2. customThe residue is partitioned between a aqueous saturated solution of sodium bicarbonate and ethyl acetate
  3. customAfter drying the organic phase
  4. customis evaporated
  5. customthe residue is dried in vacuum
  6. customA solid in quantitative yield is obtained

출처 및 근거

ORD 기록
ord-92581b61ab5249748f5b0032e571d119
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745446B2

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