5-(4-Iodo-phenyl)-7-methylsulfanyl-pyrazolo[1,5-c]pyrimidine → 3-Bromo-5-(4-iodo-phenyl)-7-methylsulfanyl-pyrazolo[1,5-c]pyrimidine

반응식

[I:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([S:14][CH3:15])[N:11]3[N:16]=[CH:17][CH:18]=[C:10]3[CH:9]=2)=[CH:4][CH:3]=1.[Br:19]N1C(=O)CCC1=O.ClC1C=CC=CC=1>>[Br:19][C:18]1[CH:17]=[N:16][N:11]2[C:10]=1[CH:9]=[C:8]([C:5]1[CH:6]=[CH:7][C:2]([I:1])=[CH:3][CH:4]=1)[N:13]=[C:12]2[S:14][CH3:15]

참가 물질

반응물 2

HCID 673194195-(4-Iodo-phenyl)-7-methylsulfanyl-pyrazolo[1,5-c]pyrimidine

HCID 86616047chlorobenzene N-bromosuccinimide

생성물 1

HCID 684269723-Bromo-5-(4-iodo-phenyl)-7-methylsulfanyl-pyrazolo[1,5-c]pyrimidine

실험 절차

To a solution of 5-(4-iodo-phenyl)-7-methylsulfanyl-pyrazolo[1,5-c]pyrimidin (1000 mg) in chlorobenzene N-bromosuccinimide (730 mg) is added. The mixture is stirred for 1 hour then the chlorobenzene is evaporated. The residue is partitioned between ethylacetate and sodium-hydrogencarbonate (5%).

후처리

customthe chlorobenzene is evaporated
customThe residue is partitioned between ethylacetate and sodium-hydrogencarbonate (5%)

출처 및 근거

ORD 기록: ord-3db5d3632b8b4049bcffda686f654c4d
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07745446B2

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