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Trifluoroacetic acid → (2S,4R)-4-Fluoro-N-(pyrazin-2-yl)pyrrolidine-2-carboxamide

HRID 1961387
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HRID 1961387 반응식
[F:1][C@H:2]1[CH2:6][N:5](C(OC(C)(C)C)=O)[C@H:4]([C:14](=[O:22])[NH:15][C:16]2[CH:21]=[N:20][CH:19]=[CH:18][N:17]=2)[CH2:3]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:1][C@H:2]1[CH2:6][NH:5][C@H:4]([C:14]([NH:15][C:16]2[CH:21]=[N:20][CH:19]=[CH:18][N:17]=2)=[O:22])[CH2:3]1
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참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 59436441(2S,4R)-tert-Butyl 4-fluoro-2-(pyrazin-2-ylcarbamoyl)pyrrolidine-1-carboxylate

생성물 1

HCID 59436310(2S,4R)-4-Fluoro-N-(pyrazin-2-yl)pyrrolidine-2-carboxamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of (2S,4R)-tert-butyl 4-fluoro-2-(pyrazin-2-ylcarbamoyl)pyrrolidine-1-carboxylate 65A (4.1 g, 12.3 mmol) in CH2Cl2 (120 mL) was added TFA (10 mL). The reaction mixture was stirred at rt overnight. After concentration in vacuo, the residue was used for the next step without purification. LC/MS [M+H]+: 211; Ret time (Method F): 0.30 min.

후처리

  1. concentrationAfter concentration in vacuo
  2. customthe residue was used for the next step without purification
  3. custom0.30 min.

출처 및 근거

ORD 기록
ord-c2169ffb5ae34a3ab17f1d73b3b440f2
출처 데이터셋
uspto-grants-2013_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08415340B2

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