Trifluoroacetic acid → (S)-Methyl 2,4,4-trimethylpyrrolidine-2-carboxylate
반응식
[CH3:1][C@@:2]1([C:16]([O:18][CH3:19])=[O:17])[CH2:6][C:5]([CH3:8])([CH3:7])[CH2:4][N:3]1C(OC(C)(C)C)=O.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][C@@:2]1([C:16]([O:18][CH3:19])=[O:17])[CH2:6][C:5]([CH3:7])([CH3:8])[CH2:4][NH:3]1참가 물질
4
실험 절차
To a stirred solution of (S)-1-tert-butyl 2-methyl 2,4,4-trimethylpyrrolidine-1,2-dicarboxylate 106D in CH2Cl2 (60 ml) was added TFA (10 mL). The reaction mixture was stirred at room temperature overnight and concentrated. The residue was used for the next step without purification.
후처리
- concentrationconcentrated
- customThe residue was used for the next step without purification
출처 및 근거
- ORD 기록
- ord-ea47e503766a446697f9f27244e5cca6
- 출처 데이터셋
- uspto-grants-2013_04
- 특허 번호
- US08415340B2
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