Trifluoroacetic acid → HCID 59436448, 화합물

HRID 1961412노트

반응식

HRID 1961412 반응식
[F:1][C:2]1([F:23])[CH2:6][N:5](C(OC(C)(C)C)=O)[C@H:4]([C:14](=[O:22])[NH:15][C:16]2[CH:21]=[N:20][CH:19]=[CH:18][N:17]=2)[CH2:3]1.FC(F)(F)C(O)=O>C(Cl)Cl>[F:23][C:2]1([F:1])[CH2:6][NH:5][C@H:4]([C:14]([NH:15][C:16]2[CH:21]=[N:20][CH:19]=[CH:18][N:17]=2)=[O:22])[CH2:3]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 59436366HCID 59436366, 화합물

생성물 1

HCID 59436448HCID 59436448, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirred solution of (S)-tert-butyl 4,4-difluoro-2-(pyrazin-2-ylcarbamoyl)pyrrolidine-1-carboxylate 116B (1.6 g, 4.87 mmol) in CH2Cl2(30 mL) was added trifluoroacetic acid (7.24 mL, 97 mmol). The mixture was stirred for 4 hrs, the solvent was evaporated to dryness and the residue 116C was used in the next reaction without further purification. LC/MS [M+H]+: 229; Ret time (Method F): 0.61 min.

후처리

  1. customthe solvent was evaporated to dryness
  2. customthe residue 116C was used in the next reaction without further purification
  3. custom0.61 min.

출처 및 근거

ORD 기록
ord-21e951c7725445469af646665a9a36b4
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08415340B2

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