4-(3,6-dihydro-2H-pyran-4-yl)benzonitrile → 4-(Tetrahydro-2H-pyran-4-yl)benzonitrile
반응식
[O:1]1[CH2:6][CH:5]=[C:4]([C:7]2[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=2)[CH2:3][CH2:2]1>CCO.[Pd]>[O:1]1[CH2:6][CH2:5][CH:4]([C:7]2[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=2)[CH2:3][CH2:2]1참가 물질
4
실험 절차
450 mg (2.43 mmol) 4-(3,6-dihydro-2H-pyran-4-yl)benzonitrile was dissolved in 15 ml EtOH and 50 mg 10% Pd/C was added. The reaction mixture was stirred under H2 (4 bar) over night at room temperature. The mixture was filtered through celite with EtOAc washing. The filtrate was concentrated and the crude product 340 mg (75% yield) was used directly in the next step.
후처리
- filtrationThe mixture was filtered through celite with EtOAc washing
- concentrationThe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-aa96eb4e222b42e7a2776e7850b6b75c
- 출처 데이터셋
- uspto-grants-2013_04
- 특허 번호
- US08415333B2
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