6-(benzyloxy)-N-(4-tert-butylbenzyl)-2-methyl-1,8-naphthyridine-3-carboxamide → N-(4-tert-Butylbenzyl)-6-hydroxy-2-methyl-1,8-naphthyridine-3-carboxamide

HRID 1961478노트

반응식

HRID 1961478 반응식
C([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[N:17][CH:18]=1)[N:15]=[C:14]([CH3:19])[C:13]([C:20]([NH:22][CH2:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]([CH3:33])([CH3:32])[CH3:31])=[CH:26][CH:25]=1)=[O:21])=[CH:12]2)C1C=CC=CC=1>CO.[Pd]>[C:30]([C:27]1[CH:26]=[CH:25][C:24]([CH2:23][NH:22][C:20]([C:13]2[C:14]([CH3:19])=[N:15][C:16]3[C:11]([CH:12]=2)=[CH:10][C:9]([OH:8])=[CH:18][N:17]=3)=[O:21])=[CH:29][CH:28]=1)([CH3:33])([CH3:31])[CH3:32]

참가 물질

4

반응물 1

HCID 667454906-(benzyloxy)-N-(4-tert-butylbenzyl)-2-methyl-1,8-naphthyridine-3-carboxamide

생성물 1

HCID 66745406N-(4-tert-Butylbenzyl)-6-hydroxy-2-methyl-1,8-naphthyridine-3-carboxamide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

6-(Benzyloxy)-N-(4-tert-butylbenzyl)-2-methyl-1,8-naphthyridine-3-carboxamide (62.0 mg, 0.14 mmol) was dissolved in MeOH (2 ml). Pd (C) (3.1 mg) was added to the solution. The mixture was hydrogenated at atmospheric pressure for 24 h. Then it was filtered through a pad of celite and concentrated under reduced pressure. The residue was washed with CH2Cl2 yielding 37 mg (76%) of the title compound.

후처리

  1. filtrationThen it was filtered through a pad of celite
  2. concentrationconcentrated under reduced pressure
  3. washThe residue was washed with CH2Cl2 yielding 37 mg (76%) of the title compound

출처 및 근거

ORD 기록
ord-cfb91ff860be49cfa1fe0c129da0799e
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08415333B2

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