4-Amino-3-nitrobenzimidamide hydrochloride → 3,4-Diaminobenzimidamide hydrochloride

HRID 1961494노트

반응식

HRID 1961494 반응식
[ClH:1].[NH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH2:9])=[NH:8])=[CH:5][C:4]=1[N+:12]([O-])=O>[OH-].[OH-].[Pd+2].CO>[ClH:1].[NH2:12][C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:3]=1[NH2:2])[C:7]([NH2:9])=[NH:8]

참가 물질

4

반응물 1

HCID 673560924-Amino-3-nitrobenzimidamide hydrochloride

생성물 1

HCID 221255323,4-Diaminobenzimidamide hydrochloride

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매2회HCID 887Methanol용매

실험 절차

A suspension of 4-amino-3-nitrobenzamidine monohydrochloride (15 g, 69 mmol) and Pearlman's catalyst [Pd(OH)2, 1.0 g, 7.12 mmol) in methanol (200 mL) was shaken under hydrogen atmosphere 50 psi for 1.5 h. The suspension was filtered through Celite and the filtrate was added dropwise to anhydrous diethyl ether (400 mL) to precipitate 3,4-diaminobenzamidine monohydrochloride as a tan solid.

후처리

  1. filtrationThe suspension was filtered through Celite
  2. additionthe filtrate was added dropwise to anhydrous diethyl ether (400 mL)
  3. customto precipitate 3,4-diaminobenzamidine monohydrochloride as a tan solid

출처 및 근거

ORD 기록
ord-e37fba752b494bc783dbf84895e147d0
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08415328B2

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