Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1961502생성일: 2026년 10월 27일
Potassium Carbonate → 3-[[4-(Methylsulfonyl)phenyl]amino]-1-phenyl-1H-pyrazole-4-carboxamide
https://huagongshe.com/reaction/1961502
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-Bromo-4-(methylsulphonyl)benzene | HCID 77014 | — |
| 반응물 | 3-amino-1-phenyl-1H-pyrazole-4-carboxamide | HCID 8831909 | — |
| 반응물 | 2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl | HCID 11155794 | — |
| 촉매 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-[[4-(Methylsulfonyl)phenyl]amino]-1-phenyl-1H-pyrazole-4-carboxamide | HCID 44626207 | — |
반응 단계
3-amino-1-phenyl-1H-pyrazole-4-carboxamide (50 mg, 0.247 mmol), 4-bromophenyl methyl sulfone (58.1 mg, 0.247 mmol), Pd2 dba3 (22.64 mg, 0.025 mmol), K2CO3 (37.6 mg, 0.272 mmol) and X-Phos (58.9 mg, 0.124 mmol) were added to a 5 mL microwave vial. Degassed EtOH (0.75 mL) was added and the vial evacuated and back-filled with N2 (×3). The resulting mixture was stirred at 100° C. for 4 hours. Room temperature was attained, MeOH was added and the solvent removed in vacuo while loading onto silica. Purification of the residue by MPLC (0-6% MeOH—CHCl3) gave 3-{[4-(methylsulfonyl)phenyl]amino}-1-phenyl-1H-pyrazole-4-carboxamide as a pale yellow solid after triturating in DCM.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08415346B2 |
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| 출처 데이터셋 | uspto-grants-2013_04 |
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| ORD ID | ord-35ec93f96f584bbd9103b8af9f73aa1d |
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| 출처 메모 | uspto-grants-2013_04 |
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