Water → N-(2,2-difluoroethyl)-2-nitroaniline

HRID 1961557

반응식

HRID 1961557 반응식
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[F:11][CH:12]([F:15])[CH2:13][NH2:14].O>C(#N)C>[F:11][CH:12]([F:15])[CH2:13][NH:14][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9]

참가 물질

5

반응물 3

HCID 962WaterHCID 69451-Chloro-2-nitrobenzeneHCID 1362742,2-Difluoroethanamine

생성물 1

HCID 58110950N-(2,2-difluoroethyl)-2-nitroaniline수율 95%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

2 ml (19 mM) of 2-Chloronitrobenzene and 2,7 ml (36 mM) of 2,2-difluoroethyl amine in 2 ml of acetonitrile were refluxed under stirring for 24 h. Water was added and the aqueous layer was extracted with ethyl acetate. The organic layer was washed with water and dried over anhydrous sodium sulfate. The solvent was removed under vacuum to give 3,65 g of N-(2,2-difluoroethyl)-2-nitroaniline as an orange solid. Yield: 95%.

후처리

  1. extractionthe aqueous layer was extracted with ethyl acetate
  2. washThe organic layer was washed with water
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was removed under vacuum

출처 및 근거

ORD 기록
ord-5777d86b5f684bf1a22cf4f9563d3f94
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08415352B2

연결된 노트

불러오는 중…