Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chlorophenylglyoxylic acid → 3-(4-chlorophenyl)-1-(2,2-difluoroethyl) quinoxalin-2(1H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chlorophenylglyoxylic acid | HCID 145998 | — |
| 반응물 | N-(2,2-difiuoroethyl)benzene-1,2-diamine | HCID 58110951 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 3-(4-chlorophenyl)-1-(2,2-difluoroethyl) quinoxalin-2(1H)-one | HCID 44224485 | 32% |
반응 단계
To a solution of 400 mg (2,32 mM) of N-(2,2-difluoroethyl)benzene-1,2-diamine in 7 ml of methanol were added 428 mg (2,32 mM) of 4-chloro-α-oxo-benzeneacetic acid. The mixture was refluxed for 3 h. A solid was filtered, washed and dried under vacuum to give 236 mg of 3-(4-chlorophenyl)-1-(2,2-difluoroethyl) quinoxalin-2(1H)-one Yield: 32%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08415352B2 |
| 출처 데이터셋 | uspto-grants-2013_04 |
| ORD ID | ord-ec45fbcb22614a7389a316755d72064c |
| 출처 메모 | uspto-grants-2013_04 |