2-Bromoethanol → HCID 58315445, 화합물
반응식
[CH3:1][N:2]([CH3:34])[C:3]([C:5]1[N:28]([CH:29]2[CH2:33][CH2:32][CH2:31][CH2:30]2)[C:8]2[N:9]=[C:10]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([C:20]([N:22]4[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]4)=[O:21])=[CH:16][N:15]=3)[N:11]=[CH:12][C:7]=2[CH:6]=1)=[O:4].Br[CH2:36][CH2:37][OH:38]>>[CH3:1][N:2]([CH3:34])[C:3]([C:5]1[N:28]([CH:29]2[CH2:33][CH2:32][CH2:31][CH2:30]2)[C:8]2[N:9]=[C:10]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([C:20]([N:22]4[CH2:27][CH2:26][N:25]([CH2:36][CH2:37][OH:38])[CH2:24][CH2:23]4)=[O:21])=[CH:16][N:15]=3)[N:11]=[CH:12][C:7]=2[CH:6]=1)=[O:4]참가 물질
3
실험 절차
Following General Procedure D, 7-cyclopentyl-2-[5-(piperazine-1-carbonyl)-pyridin-2-ylamino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (200 mL, 0.43 mmol) and 2-bromo ethanol (37 mg, 0.52 mmol) to give 7-cyclopentyl-2-{5-[4-(2-hydroxy-ethyl)-piperazine-1-carbonyl]-pyridin-2-ylamino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (100 mg, 48%). MS(ESI) m/z 478.3 (M+H)+
출처 및 근거
- ORD 기록
- ord-d13d490a363a40e1ac612d7f184fd3bb
- 출처 데이터셋
- uspto-grants-2013_04
- 특허 번호
- US08415355B2