4-Nitrophenol → 4-Nitrophenoxyacetonitrile

HRID 1962252노트

반응식

HRID 1962252 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].Br[CH2:12][C:13]#[N:14].C([O-])([O-])=O.[K+].[K+]>CC(C)=O.O>[C:13]([CH2:12][O:10][C:7]1[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=1)#[N:14]

참가 물질

6

반응물 3

HCID 9804-NitrophenolHCID 11430Potassium CarbonateHCID 11534Bromoacetonitrile

생성물 1

HCID 1418544-Nitrophenoxyacetonitrile

시약·촉매·용매 2

HCID 180Acetone용매2회HCID 962Water용매

실험 절차

4-Nitrophenol (10 g), bromoacetonitrile (6 mL) and K2CO3 (15 g) were suspended in acetone (100 mL). The yellow solution was stirred at rt overnight. The reaction mixture was diluted with water (100 mL) and acetone was removed under reduced pressure. The light-yellow precipitate was collected by filtration, washed with water and dried to give O-cyanomethyl-4-nitrophenol.

후처리

  1. customwas removed under reduced pressure
  2. filtrationThe light-yellow precipitate was collected by filtration
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-0b3e1c6377c1423aa0bc3df85194ae18
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08415365B2

반응 노트

불러오는 중…