참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Cyanide | HCID 8929 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | 1-Methoxypiperidin-4-one | HCID 19936653 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Ammonium Hydroxide | HCID 14923 | — |
| 생성물 | 4-Amino-1-methoxy-piperidine-4-carbonitrile | HCID 59614594 | 68.7% |
반응 단계
To 10 g of N-methoxy-4-piperidone (Journal of Organic Chemistry (1961), 26, 1867-74) in 240 ml of ammonium hydroxide (25% in water) was added 6.2 g of ammonium chloride and 4.6 g of sodium cyanide. After stirring for 18 hours at 25° C. the reaction mixture was diluted with 200 ml of water and extracted with ethyl acetate. The organic phase was separated, dried over sodium sulfate and evaporated. 8.25 g of 4-amino-1-methoxy-piperidine-4-carbonitrile was obtained as a light brown oil, which was used without further purification in the next step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08415369B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_04 |
|---|
| ORD ID | ord-6f889f405fcb447ab51798719fd853e6 |
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| 출처 메모 | uspto-grants-2013_04 |
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