Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butyl methyl((3R)-pyrrolidin-3-yl)carbamate → Hydrochloric Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butyl methyl((3R)-pyrrolidin-3-yl)carbamate | HCID 7019173 | — |
| 반응물 | (S)-Methyl-pyrrolidin-3-yl-carbamic acid tert-butyl ester | HCID 7171888 | — |
| 반응물 | 4-Fluoroisoquinoline-5-sulfonylchloride | HCID 11856547 | — |
| 반응물 | 4-Bromo-5-isoquinolinesulfonyl chloride | HCID 14580058 | — |
| 반응물 | (R)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(4-fluoro-5-isoquinolinesulfonyl)pyrrolidine | HCID 67243108 | — |
| 생성물 | Hydrochloric Acid | HCID 313 | — |
| 생성물 | (R)-1-(4-Fluoro-5-isoquinolinesulfonyl)-3-(methylamino)pyrrolidine | HCID 67243602 | — |
반응 단계
(R)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(4-fluoro-5-isoquinolinesulfonyl)pyrrolidine (Intermediate 22b) can be prepared by using 4-fluoro-5-isoquinolinesulfonyl chloride and (R)-3-[N-(tert-butoxycarbonyl)-N-methyl-amino]pyrrolidine in the method of Example 1-3, Step A instead of 4-bromo-5-isoquinolinesulfonyl chloride and (S)-3-[N-(tert-butoxycarbonyl)-N-methyl-amino]pyrrolidine, respectively, and then used in the method of Example 1-3, Step B in a similar manner to obtain the title compound as hydrochloride.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08415372B2 |
| 출처 데이터셋 | uspto-grants-2013_04 |
| ORD ID | ord-263a3858a46549ddb285e9547ce042da |
| 출처 메모 | uspto-grants-2013_04 |