2-(Phenylmethyl)pyridine → 2-(3-Fluoro-2-methyl-benzyl)-1-phenyl-indolizine

HRID 1963043노트

반응식

HRID 1963043 반응식
Br[CH2:2][C:3](=O)[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:6]=1[CH3:12].[CH2:14]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>CC(C)=O>[F:11][C:7]1[C:6]([CH3:12])=[C:5]([CH:10]=[CH:9][CH:8]=1)[CH2:4][C:3]1[C:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:21]2[N:22]([CH:2]=1)[CH:23]=[CH:24][CH:25]=[CH:26]2

참가 물질

4

반응물 2

HCID 75812-(Phenylmethyl)pyridineHCID 866706671-Bromo-3-(3-fluoro-2-methyl-phenyl)-propan-2-one

생성물 1

HCID 677730242-(3-Fluoro-2-methyl-benzyl)-1-phenyl-indolizine수율 33.8%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

The compound of step 2 (1.50 g, 6.12 mmol) and 2-benzyl-pyridine (2.071 g, 12.24 mmol) were dissolved in acetone (30 ml) and the mixture was stirred under reflux overnight. The mixture was concentrated to dryness and the residue was purified by chromatography on silica gel (cyclohexane) to give 0.653 g of the title compound.

후처리

  1. temperatureunder reflux overnight
  2. concentrationThe mixture was concentrated to dryness
  3. customthe residue was purified by chromatography on silica gel (cyclohexane)

출처 및 근거

ORD 기록
ord-a857ff382b0a4e8abaa8d4ebf918fd2d
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08415336B2

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