2-(Phenylmethyl)pyridine → HCID 67772676, 화합물

HRID 1963049노트

반응식

HRID 1963049 반응식
Br[CH2:2][C:3](=O)[CH2:4][C:5]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:12].[CH2:14]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>CC(C)=O>[Cl:12][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]([F:11])[C:5]=1[CH2:4][C:3]1[C:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:21]2[N:22]([CH:2]=1)[CH:23]=[CH:24][CH:25]=[CH:26]2

참가 물질

4

반응물 2

HCID 75812-(Phenylmethyl)pyridineHCID 80147526HCID 80147526, 화합물

생성물 1

HCID 67772676HCID 67772676, 화합물수율 76.3%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

The compound of step 1 (1.17 g, 4.41 mmol) and 2-benzyl-pyridine (1.49 g, 8.82 mmol) were dissolved in acetone (15 ml) and the mixture was stirred under reflux overnight. The mixture was concentrated to dryness and the residue was purified by chromatography on silica gel (DCM/MOH, 100:0, then 95:5) to give 1.13 g of the title compound.

후처리

  1. temperatureunder reflux overnight
  2. concentrationThe mixture was concentrated to dryness
  3. customthe residue was purified by chromatography on silica gel (DCM/MOH, 100:0

출처 및 근거

ORD 기록
ord-f019980b3a7a4707b5c4643159388c93
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08415336B2

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