6-(2-methylpropyl)piperidine-2,4-dione → HCID 66732004, 화합물

HRID 1963109노트

반응식

HRID 1963109 반응식
[H-].[H-].[H-].[H-].[Li+].[Al+3].[CH2:7]([CH:11]1[NH:16][C:15](=O)[CH2:14][C:13](=[O:18])[CH2:12]1)[CH:8]([CH3:10])[CH3:9]>C1COCC1>[CH2:7]([CH:11]1[CH2:12][CH:13]([OH:18])[CH2:14][CH2:15][NH:16]1)[CH:8]([CH3:10])[CH3:9]

참가 물질

4

반응물 2

HCID 52466806-(2-methylpropyl)piperidine-2,4-dioneHCID 21226445Aluminium lithium hydride

생성물 1

HCID 66732004HCID 66732004, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a stirred ice cooled suspension of LAH (16.1 g, 0.414 mol) in THF (100 mL), a solution of 6-isobutyl-piperidine-2,4-dione (14.0 g, 0.083 mol) in THF (100 mL) was added dropwise under N2. The reaction mixture was warmed to room temperature and stirred under N2 for 48 h. The reaction mixture was cooled to 0° C. and quenched with water (16.1 mL), 1 N NaOH (16.1 mL) and water (16.1 mL). The reaction mixture was filtered and the solid was washed with hot THF (100 mL). The filtrate was concentrated to yield 2-isobutyl-piperidin-4-ol as a solid (9 g, crude).

후처리

  1. temperatureThe reaction mixture was cooled to 0° C.
  2. customquenched with water (16.1 mL), 1 N NaOH (16.1 mL) and water (16.1 mL)
  3. filtrationThe reaction mixture was filtered
  4. washthe solid was washed with hot THF (100 mL)
  5. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-8dc02dea70b647bd93facac53becd429
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08415378B2

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