Iodine → HCID 178506003, 화합물

HRID 1963252노트

반응식

HRID 1963252 반응식
[Zn:1].II.[Br:4][CH2:5][CH:6]1[CH2:11][CH2:10][C:9]([F:13])([F:12])[CH2:8][CH2:7]1>CC(N(C)C)=O>[Br-:4].[F:12][C:9]1([F:13])[CH2:10][CH2:11][CH:6]([CH2:5][Zn+:1])[CH2:7][CH2:8]1

참가 물질

5

반응물 3

HCID 807IodineHCID 23994ZincHCID 533503614-(Bromomethyl)-1,1-difluorocyclohexane

생성물 1

HCID 178506003HCID 178506003, 화합물

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

반응 조건

온도
70 °C

실험 절차

Zinc powder (1.43 g, 21.87 mmol) was added to a dried flask and was heated at 70° C. under vacuum for 30 minutes. Dry DMA (29 mL) and iodine (0.092 g, 0.37 mmol) were added and the mixture was heated at 70° C. until the red-brown colour had disappeared (approx. 5 minutes). 4-(Bromomethyl)-1,1-difluorocyclohexane (3.1 g, 14.55 mmol) was added and heating was continued for ca. 42 h. The resulting solution was used in the next transformation.

후처리

  1. temperaturethe mixture was heated at 70° C. until the red-brown colour
  2. custom(approx. 5 minutes)
  3. temperatureheating

출처 및 근거

ORD 기록
ord-515558435e7646caacaf978344a2cf2a
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08415378B2

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