Ethyl Acetate → HCID 66878221, 화합물

HRID 1963999

반응식

HRID 1963999 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[C:10]([NH2:15])[CH:9]=2)=[CH:4][CH:3]=1.[C:16](=[O:19])([O-])[O-:17].[K+].[K+].[C:22](OCC)(=[O:24])C>C1COCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[C:10]([NH:15][C:22](=[O:24])[C:16]([OH:17])=[O:19])[CH:9]=2)=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 463144304'-Fluoro-4-methylbiphenyl-3-amine

생성물 1

HCID 66878221HCID 66878221, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
0 °C

실험 절차

2.0 g (9.9 mmol) of 4′-fluoro-4-methylbiphenyl-3-amine and 1.64 g (11.9 mmol) of potassium carbonate were suspended in THF, and 1.49 g (10.9 mmol) of chloroglyoxylic acid ethyl were added thereto at 0° C., and stirred at room temperature for 4 hours. After completion of the reaction, ethyl acetate was added to the mixture, and the mixture was washed with an aqueous sodium bicarbonate solution and a sodium chloride solution in this order. The resulting organic layer was dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure to give 2.76 g of [(4′-fluoro-4-methylbiphenyl-3-yl)amino] (oxo)acetic acid.ethyl ester (yield: 93%).

후처리

  1. additionwas added to the mixture
  2. washthe mixture was washed with an aqueous sodium bicarbonate solution
  3. dry with materialThe resulting organic layer was dried over anhydrous sodium sulfate
  4. distillationthe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-5096bb7463014ed393a503b841547087
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08415479B2

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