Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cesium carbonate → N-ethyl-5-(furan-3-yl)-2-methylaniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 2-(Furan-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 2773996 | — |
| 반응물 | 5-bromo-N-ethyl-2-methylaniline | HCID 43729699 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-ethyl-5-(furan-3-yl)-2-methylaniline | HCID 66877311 | 98% |
반응 단계
0.69 g (3.20 mmol) of 5-bromo-N-ethyl-2-methylaniline and 0.93 g (4.80 mmol) of 3-furan boronic acid pinacol ester were dissolved in 7 mL of THF. 1.56 g (4.80 mmol) of cesium carbonate and 370 mg (0.32 mmol) of tetrakis(triphenyl phosphine)palladium(0) were added thereto and heated under reflux for 22 hours. After completion of the reaction, filtration was conducted, and the filtrate was condensed. The resulting crude product was separated and purified using silica gel column chromatography to give N-ethyl-5-(furan-3-yl)-2-methylaniline (yield: 98%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08415479B2 |
| 출처 데이터셋 | uspto-grants-2013_04 |
| ORD ID | ord-6f317208b33b4f2a8539517b604f631b |
| 출처 메모 | uspto-grants-2013_04 |