(2,6-Dimethoxypyridin-3-yl)boronic acid → HCID 44251372, 화합물

HRID 1964025노트

반응식

HRID 1964025 반응식
[CH3:1][O:2][C:3]1[C:8](B(O)O)=[CH:7][CH:6]=[C:5]([O:12][CH3:13])[N:4]=1.Br[C:15]1[CH:16]=[C:17]([NH:21][C:22](=[O:39])[CH2:23][O:24][CH2:25][C:26]([NH:28][C:29]2[CH:37]=[CH:36][C:35]([Cl:38])=[CH:34][C:30]=2[C:31]([OH:33])=[O:32])=[O:27])[CH:18]=[CH:19][CH:20]=1>>[Cl:38][C:35]1[CH:36]=[CH:37][C:29]([NH:28][C:26](=[O:27])[CH2:25][O:24][CH2:23][C:22]([NH:21][C:17]2[CH:18]=[CH:19][CH:20]=[C:15]([C:8]3[C:3]([O:2][CH3:1])=[N:4][C:5]([O:12][CH3:13])=[CH:6][CH:7]=3)[CH:16]=2)=[O:39])=[C:30]([CH:34]=1)[C:31]([OH:33])=[O:32]

참가 물질

3

반응물 2

HCID 2762707(2,6-Dimethoxypyridin-3-yl)boronic acidHCID 86653349HCID 86653349, 화합물

생성물 1

HCID 44251372HCID 44251372, 화합물

실험 절차

Using the same method as in Example 19-(ii), 2,6-dimethoxy-3-pyridine boronic acid was reacted with the 2-[((2-[(3-bromophenyl)amino]-2-oxoethoxy)acetyl)amino]-5-chlorobenzoic acid.methyl ester obtained in Example 19-(i) to give 5-chloro-2-([(2-([3-(2,6-dimethoxypyridin-3-yl)phenyl]amino)-2-oxoethoxy)acetyl]amino)benzoic acid.methyl ester (yield: 51%).

출처 및 근거

ORD 기록
ord-6f089b7dd4ec49ae888bbbe189b1ac54
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08415479B2

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