1-(3,3-Dimethyl-6-nitroindolin-1-yl)ethanone → 1-(6-Amino-3,3-dimethylindolin-1-yl)ethanone

HRID 19645노트

반응식

HRID 19645 반응식
[CH3:1][C:2]1([CH3:17])[C:10]2[C:5](=[CH:6][C:7]([N+:11]([O-])=O)=[CH:8][CH:9]=2)[N:4]([C:14](=[O:16])[CH3:15])[CH2:3]1>[Pd].CCO>[NH2:11][C:7]1[CH:6]=[C:5]2[C:10]([C:2]([CH3:17])([CH3:1])[CH2:3][N:4]2[C:14](=[O:16])[CH3:15])=[CH:9][CH:8]=1

참가 물질

4

반응물 1

HCID 161274181-(3,3-Dimethyl-6-nitroindolin-1-yl)ethanone

생성물 1

HCID 218651761-(6-Amino-3,3-dimethylindolin-1-yl)ethanone수율 99.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 1-(3,3-dimethyl-6-nitroindolin-1-yl)ethanone (300 mg), 10% Pd—C (50 mg), and EtOH (50 mL) was stirred under hydrogen atmosphere (1 atm) for 3 h. The catalyst was filtered out and the filtrate was concentrated to give a light yellow solid (260 mg).

후처리

  1. filtrationThe catalyst was filtered out
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-8ecd7fd50f4d41ec96250d47380662a3
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745451B2

반응 노트

불러오는 중…