(1,1'-Biphenyl)-4-sulphonyl chloride → [1,1'-biphenyl]-4-ylsulfonyl-N-[1-(4-fluorophenyl)ethyl]-1,3-thiazolidine-2-carboxamide

HRID 1964834

반응식

C(OC([N:8]1[CH2:12][CH2:11][S:10][CH:9]1[C:13]([OH:15])=O)=O)(C)(C)C.C1C=CC(/C(/C2C=CC([N+]([O-])=O)=CC=2)=N/O)=CC=1.[C:34]1([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)[CH:39]=[CH:38][C:37]([S:40](Cl)(=[O:42])=[O:41])=[CH:36][CH:35]=1.[F:50][C:51]1[CH:56]=[CH:55][C:54]([CH:57]([NH2:59])[CH3:58])=[CH:53][CH:52]=1>>[C:34]1([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)[CH:39]=[CH:38][C:37]([S:40]([C:9]2([C:13]([NH:59][CH:57]([C:54]3[CH:55]=[CH:56][C:51]([F:50])=[CH:52][CH:53]=3)[CH3:58])=[O:15])[NH:8][CH2:12][CH2:11][S:10]2)(=[O:42])=[O:41])=[CH:36][CH:35]=1

참가 물질

반응물 4

HCID 74192(1,1'-Biphenyl)-4-sulphonyl chloride

HCID 1230631-(4-Fluorophenyl)ethylamine

HCID 46440943-(tert-Butoxycarbonyl)-1,3-thiazolidine-2-carboxylic acid

HCID 6506582Benzophenone, 4-nitro-, oxime

생성물 1

HCID 86623754[1,1'-biphenyl]-4-ylsulfonyl-N-[1-(4-fluorophenyl)ethyl]-1,3-thiazolidine-2-carboxamide

실험 절차

Following the general solid phase method as outlined Example 33, starting from 3-(tert-butoxycarbonyl)-1,3-thiazolidine-2-carboxylic acid, Kaiser oxime resin, 1,1′-biphenyl-4-sulfonyl chloride and 1-(4-fluorophenyl)ethanamine, the title compound was obtained in 85% purity by HPLC.

출처 및 근거

ORD 기록: ord-cb548e31f4f04ef2b50fb57698f1c289
출처 데이터셋: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08415480B2

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