1H-Pyrrolo(2,3-b)pyridine → 3-[3-(4-chloro-benzyloxy)-2-ethoxy-benzyl]1H-pyrrolo[2,3-b]pyridine

HRID 1964949

반응식

HRID 1964949 반응식
ICC(F)(F)F.ClC1C=CC(CBr)=C(F)C=1.N1C2C(=CC=CN=2)C=C1.COC1C=C2C(=NC=1)NC=C2.CCC1N=C(CC2C=CC(OC)=CC=2)OC1.[Cl:53][C:54]1[CH:83]=[CH:82][C:57]([CH2:58][O:59][C:60]2[C:61]([O:79][CH2:80][CH3:81])=[C:62]([C:66]([C:68]3[C:76]4[C:71](=[N:72][CH:73]=[C:74](OC)[CH:75]=4)[NH:70][CH:69]=3)=O)[CH:63]=[CH:64][CH:65]=2)=[C:56](F)[CH:55]=1>>[Cl:53][C:54]1[CH:55]=[CH:56][C:57]([CH2:58][O:59][C:60]2[C:61]([O:79][CH2:80][CH3:81])=[C:62]([CH:63]=[CH:64][CH:65]=2)[CH2:66][C:68]2[C:76]3[C:71](=[N:72][CH:73]=[CH:74][CH:75]=3)[NH:70][CH:69]=2)=[CH:82][CH:83]=1

참가 물질

7

반응물 6

HCID 92221H-Pyrrolo(2,3-b)pyridineHCID 677091,1,1-Trifluoro-2-iodoethaneHCID 27365514-Chloro-2-fluorobenzyl bromideHCID 3041214Oxazole, 4,5-dihydro-4-ethyl-2-((4-methoxyphenyl)methyl)-, (+-)-HCID 103078715-methoxy-1H-pyrrolo[2,3-b]pyridineHCID 58086972[3-(4-chloro-2-fluoro-benzyloxy)-2-ethoxy-phenyl]-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone

생성물 1

HCID 580877113-[3-(4-chloro-benzyloxy)-2-ethoxy-benzyl]1H-pyrrolo[2,3-b]pyridine

실험 절차

were prepared following the protocol of Scheme 71, substituting iodoethane with iodomethane in Step 3 to provide P-1891, or substituting iodoethane with 2-iodo-1,1,1-trifluoroethane in Step 3 to provide P-2076, or substituting 4-chlorobenzyl bromide 557 with 4-chloro-2-fluoro-benzyl bromide in Step 1 and 7-azaindole 94 with 5-methoxy-7-azaindole in Step 4 to provide P-2016. MS(ESI) [M+H+]+=393.4 (P-1891), 461.08 (P-2076), and 455.2 (P-2016).

후처리

  1. customto provide P-2076
  2. customto provide P-2016

출처 및 근거

ORD 기록
ord-719c9062d7554d7d8a61bc71af41d6af
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08415469B2

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