2-(Bromomethyl)-5-(trifluoromethyl)furan → 6-fluoro-2'-oxo-1'-[(2R)-tetrahydrofuran-2-ylmethyl]-1',2'-dihydrospiro[1-benzofuran-3,3'-indole]-5-carbonitrile

반응식

CC1C=CC(S(O[CH2:12][C@H:13]2[CH2:17][CH2:16][CH2:15][O:14]2)(=O)=O)=CC=1.BrCC1OC(C(F)(F)F)=CC=1.[F:29][C:30]1[C:35]([C:36]#[N:37])=[CH:34][C:33]2[C:38]3([CH2:48][O:49][C:32]=2[CH:31]=1)[C:46]1[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=1)[NH:40][C:39]3=[O:47].CC1C2C=C3C4(C5C(=CC=CC=5)NC4=O)COC3=CC=2ON=1>>[F:29][C:30]1[C:35]([C:36]#[N:37])=[CH:34][C:33]2[C:38]3([CH2:48][O:49][C:32]=2[CH:31]=1)[C:46]1[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=1)[N:40]([CH2:12][C@H:13]1[CH2:17][CH2:16][CH2:15][O:14]1)[C:39]3=[O:47]