Sulfuryl chloride → 5-Bromo-2-chloro-1,3-benzothiazole

반응식

S(Cl)([Cl:4])(=O)=O.[Br:6][C:7]1[CH:8]=[CH:9][C:10]2[S:14][C:13](S)=[N:12][C:11]=2[CH:16]=1>>[Br:6][C:7]1[CH:8]=[CH:9][C:10]2[S:14][C:13]([Cl:4])=[N:12][C:11]=2[CH:16]=1

참가 물질

반응물 2

HCID 24648Sulfuryl chloride

HCID 178527757HCID 178527757, 화합물

생성물 1

HCID 202512695-Bromo-2-chloro-1,3-benzothiazole수율 100%

실험 절차

To sulfuryl dichloride (5 mL) was added 5-bromobenzo[d]thiazole-2-thiol (450 mg, 1.8 mmol) portionwise. The mixture was stirred at rt for 1 hour and heated at 50° C. for 15 min. After cooling to rt, the reaction mixture was slowly poured onto ice (50 g) and the resulting suspension was stirred for 30 min. Solid was collected through filtration and washed with water (10 mL) and dried under high vacuum to afford 5-bromo-2-chlorobenzo[d]thiazole as a pink solid (470 mg, 100%). MS (ESI) m/z 248 (M+H+).

후처리

temperatureheated at 50° C. for 15 min
temperatureAfter cooling to rt
additionthe reaction mixture was slowly poured onto ice (50 g)
stirringthe resulting suspension was stirred for 30 min
filtrationSolid was collected through filtration
washwashed with water (10 mL)
customdried under high vacuum

출처 및 근거

ORD 기록: ord-28443ae781844559a83c7081fbfc3abf
출처 데이터셋: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08420052B2

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