Tetrahydrofuran → N,N-dimethyl-2-[methyl-(2-pyridine-4-yl-ethyl)-amino]-acetamide

HRID 1965944노트

반응식

HRID 1965944 반응식
[CH3:1][NH:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1.[CH3:11][N:12]([CH3:17])[C:13](=[O:16])[CH2:14]Cl.C(=O)(O)[O-].[Na+].O1CCCC1>CO>[CH3:11][N:12]([CH3:17])[C:13](=[O:16])[CH2:14][N:2]([CH3:1])[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1

참가 물질

6

반응물 4

HCID 8028TetrahydrofuranHCID 758862-chloro-N,N-dimethylacetamideHCID 143276Methyl[2-(pyridin-4-yl)ethyl]amineHCID 516892Sodium Bicarbonate

생성물 1

HCID 21081298N,N-dimethyl-2-[methyl-(2-pyridine-4-yl-ethyl)-amino]-acetamide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

4-[2-(methylamino)ethyl]pyridine (34.4 g) and 29.18 g of chloroacetic acid-dimethylamide are dissolved in 200 ml of methanol. After the addition of 20 g of sodium bicarbonate the mixture is refluxed for 5 hours with stirring. For working up the mixture is combined with 1000 ml of tetrahydrofuran, decanted off from the precipitated salts and the solution is filtered through active charcoal. After the limination of the solvent, N,N-dimethyl-2-[methyl-(2-pyridine-4-yl-ethyl)-amino]-acetamide is obtained as a crude product.

후처리

  1. temperatureis refluxed for 5 hours
  2. customdecanted off from the precipitated salts
  3. filtrationthe solution is filtered through active charcoal

출처 및 근거

ORD 기록
ord-b2be16b18a5f48e1b6b82760038f2a74
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08420630B2

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