Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chloroethyl isocyanate → 1-But-3-ynyl-3-(2-chloro-ethyl)-urea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chloroethyl isocyanate | HCID 16035 | — |
| 반응물 | But-3-yn-1-amine | HCID 10034574 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 1-But-3-ynyl-3-(2-chloro-ethyl)-urea | HCID 59787366 | 100% |
반응 단계
Add chloroethyl isocyanate (5.25 g, 50 mmol) dropwise to a solution of but3-ynyl-amine (3.4 g, 50 mmol) (prepared by following the procedure described in Tetrahedron Lett. 1987, 43, 5145) in ethyl ether (100 mL). Stir the suspension for 30 min and filter the solid to obtain the desired intermediate (8.7 g, 100%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08420631B2 |
| 출처 데이터셋 | uspto-grants-2013_04 |
| ORD ID | ord-7a5f8d6b5fc64492901a3aff656875a6 |
| 출처 메모 | uspto-grants-2013_04 |