Acrylonitrile → HCID 17943388, 화합물
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:13][CH2:12][CH2:11][NH:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].[C:14](#[N:17])[CH:15]=[CH2:16]>CO>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:13][CH2:12][CH2:11][N:10]2[CH2:16][CH2:15][C:14]#[N:17])[CH:5]=[CH:6][C:7]=1[Cl:8]참가 물질
4
실험 절차
To the solution of 2.4 g (11.2 mmol) 2-(3,4-dichlorophenyl)pyrrolidine in 13 ml abs. methanol dropwise under stirring at room temperature 2.21 ml (33.6 mmol) acrylonitrile is added. The reaction mixture is stirred for 3 days at room temperature, then evaporated. The residue is purified by column chromatography using at first chloroform, then chloroform:methanol 100:1 ratio mixture as eluent, to obtain 2.1 g title compound in the form of an oil. LC-MS[MH+]=269 (C13H14Cl2N2 269.14).
후처리
- additionis added
- customevaporated
- customThe residue is purified by column chromatography
출처 및 근거
- ORD 기록
- ord-ea5a2e1dcd564687afacaa3667336951
- 출처 데이터셋
- uspto-grants-2013_04
- 특허 번호
- US08420636B2
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