Dimethylformamide → 1-(Cyanomethyl)-3-methylenecyclobutanecarbonitrile
반응식
CS(O[CH2:6][C:7]1([C:12]#[N:13])[CH2:10][C:9](=[CH2:11])[CH2:8]1)(=O)=O.[C-]#N.[K+].[CH3:17][N:18](C)C=O>O>[C:17]([CH2:6][C:7]1([C:12]#[N:13])[CH2:10][C:9](=[CH2:11])[CH2:8]1)#[N:18]참가 물질
5
반응 조건
- 온도
- 65 °C
실험 절차
A mixture of (1-cyano-3-methylenecyclobutyl)methyl methanesulfonate (0.41 g, 0.0020 mol) and potassium cyanide (0.66 g, 0.010 mol) in N,N-dimethylformamide (5 mL, 0.06 mol) was heated at 65° C. overnight. After diluting with water, the resulting mixture was extracted with EtOAc. The combined organic layers were washed with water, brine, dried and evaporated to dry. The residue was used directly in next step.
후처리
- extractionthe resulting mixture was extracted with EtOAc
- washThe combined organic layers were washed with water, brine
- customdried
- customevaporated
- customto dry
출처 및 근거
- ORD 기록
- ord-39663aa97586452ca0f4c81c898b239e
- 출처 데이터셋
- uspto-grants-2013_04
- 특허 번호
- US08420629B2
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