홈 MCP 워크벤치 Skills

홈 워크벤치 알림 마이페이지

llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0

홈
반응

Water → [5-(4-Methanesulfonyl-phenoxy)-3-(2-methoxy-ethoxy)-pyridine-2-yl]-thiourea

HRID 1966255

인쇄 미리보기

반응식

HRID 1966255 반응식

[CH3:1][S:2]([C:5]1[CH:23]=[CH:22][C:8]([O:9][C:10]2[CH:11]=[C:12]([O:17][CH2:18][CH2:19][O:20][CH3:21])[C:13]([NH2:16])=[N:14][CH:15]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].C1N=C[N:26]([C:29](N2C=NC=C2)=[S:30])C=1.[NH4+].[OH-].O>C1COCC1>[CH3:1][S:2]([C:5]1[CH:23]=[CH:22][C:8]([O:9][C:10]2[CH:11]=[C:12]([O:17][CH2:18][CH2:19][O:20][CH3:21])[C:13]([NH:16][C:29]([NH2:26])=[S:30])=[N:14][CH:15]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3]

참가 물질 실험 절차 후처리 출처 및 근거 반응 노트

참가 물질

6

반응물 4

HCID 14923Ammonium Hydroxide

HCID 802641,1'-Thiocarbonyldiimidazole

HCID 674864395-(4-Methanesulfonyl-phenoxy)-3-(2-methoxy-ethoxy)-pyridine-2-ylamine

생성물 1

HCID 86644610[5-(4-Methanesulfonyl-phenoxy)-3-(2-methoxy-ethoxy)-pyridine-2-yl]-thiourea수율 75%

시약·촉매·용매 1

HCID 8028

Tetrahydrofuran

용매

실험 절차

5-(4-Methanesulfonyl-phenoxy)-3-(2-methoxy-ethoxy)-pyridine-2-ylamine (0.37 mmol) is dissolved in THF (5.5 ml) and 1,1-thiocarbonyldiimidazole (4 eq.) is added. The reaction solution is stirred 3 days. 32% NH4OH (20 eq.) is added and stirred 4 hours at room temperature. Water (150 ml) is added and extracted with dichloromethane. The combined organic layers are washed with brine and dried over MgSO4. The solvent is removed in vacuo. [5-(4-Methanesulfonyl-phenoxy)-3-(2-methoxy-ethoxy)pyridine-2-yl]-thiourea is obtained as brown oil in a yield of 75%. HPLC (method C): 1.60 min; LC-MS (method A): 1.37 min, 398.15 (MH+).

후처리

stirringstirred 4 hours at room temperature
extractionextracted with dichloromethane
washThe combined organic layers are washed with brine
dry with materialdried over MgSO4
customThe solvent is removed in vacuo

출처 및 근거

ORD 기록: ord-cd146b7cef6d4a36b01a504c39f80e08
출처 데이터셋: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08420642B2

반응 노트

불러오는 중…

이 페이지에서참가 물질 실험 절차 후처리 출처 및 근거 반응 노트